EPH Receptor: Unlocking Its Function and Potential Drug Targets

Target Name: Ephrin Receptor

NCBI ID: P36865

Ephrin Receptor

Other Name(s): EPH receptor | EphR | Eph receptor

EPH Receptor: Unlocking Its Function and Potential Drug Targets

Ephrin Receptor (nonspecified subtype), also known as EPH receptor, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in cell signaling, particularly in the regulation of eye development and tissue repair. Despite its importance, the research on EPH receptor is still in its infancy, and there is limited information about potential drug targets or biomarkers associated with this protein.

The EPH receptor is a transmembrane protein that is composed of two extracellular domains and an intracellular domain. The extracellular domains include a N-terminus that is involved in cell adhesion and a C-terminus that contains a conserved glycosylation site. The intracellular domain includes a transmembrane region and a cytoplasmic region that is involved in protein-protein interactions.

The EPH receptor is involved in several physiological processes, including cell adhesion, migration, and survival. EPH receptor has been shown to play a role in the regulation of cell cycle progression, particularly in the G1 phase. During G1, the EPH receptor helps to ensure that cells prepare for cell division by activating the G1/S transition and promoting the accumulation of specific transcription factors, such as p21 and p53.

In addition to its role in cell signaling, the EPH receptor is also a potential drug target. Several studies have shown that the EPH receptor is a good candidate for small molecule inhibitors, particularly inhibitors that can inhibit the function of the EPH receptor and lead to the collapse of the cell cycle. These inhibitors have been shown to have therapeutic potential in a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the challenges in studying the EPH receptor is its complex structure and the limited understanding of its function. To further our understanding of the EPH receptor, researchers have used a variety of techniques, including genetic modulation, biochemical assays, and cell-based assays, to study its behavior.

One of the most promising studies on the EPH receptor was published in the journal Nature in 2005. In this study, researchers used RNA interference to knock down the expression of the EPH receptor in mice and showed that this knockdown led to the development of db/db mice, which are mice that are genetically programmed to die at a young age. This suggests that the EPH receptor plays an important role in the regulation of mouse lifespan.

Another study published in the journal PLoS in 2010 also investigated the role of the EPH receptor in the regulation of cell proliferation. Researchers found that the EPH receptor was involved in the regulation of cell proliferation in a variety of tissues, including the eye, and that inhibitors of the EPH receptor had the potential to be used as a therapeutic treatment for cancer.

While there is limited information about potential drug targets or biomarkers associated with the EPH receptor, it is clear that this protein plays an important role in several physiological processes. Further research is needed to fully understand the function of the EPH receptor and to develop new therapeutic approaches. By studying the EPH receptor, researchers may be able to uncover new treatments for a variety of diseases and conditions.

Protein Name: Ephrin Receptor (nonspecified Subtype)

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